APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody reacts with C-terminal part of beta-catenin, an 88 kDa multifunctional protein involved both in cell adhesion and in activation of transcription.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human beta-catenin
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CTNNB , CTNNB1 , MRD19 , armadillo , catenin beta 1 , beta Catenin , Catenin-β , β Catenin
Cellular Localization
Cytoplasm,Nucleus,Cytoskeleton,Cell junction,Adherens junction,Cell membrane,Microtubule organizing center,Centrosome,Spindle pole,Synapse
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Database
Research Area
DATA IMAGES
![Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159](/templates/default/js/lightbox/images/loading.gif "Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159")
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GTX80159 ICC/IF Image
ICC/IF analysis of HT29 cells using GTX80159 beta Catenin antibody [EM-22].
Green : Primary antibody
Blue : DAPI
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GTX80159 WB Image
WB analysis of 3T3 (A), C57 (B) and KW1 (C) cell lysates using GTX80159 beta Catenin antibody [EM-22].
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REFERENCE
There are currently no references for beta Catenin antibody [EM-22] (GTX80159). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for beta Catenin antibody [EM-22] (GTX80159). Be the first to share your experience with this product.
![Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159](/upload/website/prouct_img/small/GTX80159/GTX80159_20191028_ICC-IF_1_w_23061322_986.webp "Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159")
![Anti-beta Catenin antibody [EM-22] used in Western Blot (WB). GTX80159](/upload/website/prouct_img/small/GTX80159/GTX80159_20191028_WB_1_w_23061322_383.webp "Anti-beta Catenin antibody [EM-22] used in Western Blot (WB). GTX80159")
![Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159](/upload/website/prouct_img/normal/GTX80159/GTX80159_20191028_ICC-IF_1_w_23061322_986.webp "Anti-beta Catenin antibody [EM-22] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80159")
![Anti-beta Catenin antibody [EM-22] used in Western Blot (WB). GTX80159](/upload/website/prouct_img/normal/GTX80159/GTX80159_20191028_WB_1_w_23061322_383.webp "Anti-beta Catenin antibody [EM-22] used in Western Blot (WB). GTX80159")