APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.2-2.5 ug/ml |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
HCT116 , human fetal heart
PROPERTIES
Form
Liquid
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to an Internal region of Human beta Catenin.
Purification
Affinity Purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo
Cellular Localization
Cytoplasm,Nucleus,Cytoplasm, cytoskeleton,Cell junction,Cell membrane,Cell junction, synapse
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Database
Research Area
DATA IMAGES
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GTX10342 ChIP assay Image
ChIP analysis of HCT116 cells using GTX10342 CTNNB1 antibody. Cells were prepared using the Farnham ChIP protocol. Use 2μg antibody GTX10342 CTNNB1 antibody for ChIP assay.
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GTX10342 WB Image
WB analysis of human fetal heart tissue using GTX10342 CTNNB1 antibody at 0.2-1μg/ml.
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GTX10342 WB Image
WB analysis of HCT116 cells using GTX10342 CTNNB1 antibody at 1:1000.
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GTX10342 ChIP assay Image
ChIP analysis of HCT116 cells using GTX10342 CTNNB1 antibody. Cells were prepared using the Farnham ChIP protocol. Use 2μg antibody GTX10342 CTNNB1 antibody for ChIP assay.
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REFERENCE
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REVIEW
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