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beta Catenin antibody

Anti-beta Catenin antibody used in IHC (Paraffin sections) (IHC-P). GTX34438
Anti-beta Catenin antibody used in IHC (Paraffin sections) (IHC-P). GTX34438
Anti-beta Catenin antibody used in Western Blot (WB). GTX34438
Anti-beta Catenin antibody used in Flow cytometry (FACS). GTX34438

Cat No. GTX34438

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, FACS

Reactivity

Human, Mouse
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT
FACS 0.5-1μg/10⁶ cells

Note :

IHC-P
Staining of formalin-fixed tissues require heating tissue sections in 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

86 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

A synthetic peptide from the middle of beta-Catenin (CTNNB1) protein

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CTNNB , CTNNB1 , MRD19 , armadillo , catenin beta 1 , beta Catenin , Catenin-β , β Catenin

Cellular Localization

Cytoplasm,Nucleus,Cytoskeleton,Cell junction,Adherens junction,Cell membrane,Microtubule organizing center,Centrosome,Spindle pole,Synapse

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Database

Research Area

DATA IMAGES

Anti-beta Catenin antibody used in IHC (Paraffin sections) (IHC-P). GTX34438

GTX34438 IHC-P Image

IHC-P analysis of breast lobular carcinoma tissue using GTX34438 beta Catenin antibody.

Anti-beta Catenin antibody used in IHC (Paraffin sections) (IHC-P). GTX34438

GTX34438 IHC-P Image

IHC-P analysis of breast ductal carcinoma tissue using GTX34438 beta Catenin antibody.

Anti-beta Catenin antibody used in Western Blot (WB). GTX34438

GTX34438 WB Image

WB analysis of human brain (1) absence, or (2) presence of immunizing peptide, and (3) mouse brain lysates using GTX34438 beta Catenin antibody.

Anti-beta Catenin antibody used in Flow cytometry (FACS). GTX34438

GTX34438 FACS Image

FACS analysis of PFA-fixed HeLa cells using GTX34438 beta Catenin antibody.
Blue : Primary antibody
Red : Isotype control

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339