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beta Tubulin 4 antibody [ONS.1A6]

Cat. No. GTX11315

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 ONS.1A6

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat, Bovine, Hamster, Chicken
Package
100 μl ($399)
See all beta Tubulin 4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:400
ICC/IF Assay dependent
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Positive Control

MCF7

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

synthetic peptide corresponding to the C-terminal sequence of β-tubulin isotype IV, conjugated to BSA.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tubulin beta 4A class IVa , DYT4 , TUBB4 , beta-5

Cellular Localization

Cytoplasm, cytoskeleton

Background

The major building block of microtubules is tubulin, an intracellular cylindrical filamentous structure that is present in almost all eukaryotic cells. Except in the simplest eukaryotes, tubulin exists in all cells as a 100 kD protein, a heterodimer of two similar but not identical polypeptides, designated alpha and beta, that assembles into microtubules. Both alpha and beta tubulins consist of various isotypes. For beta tubulin, six evolutionarily conserved isotypes were identified (designated beta I-beta VI). Beta IV exists as two subtypes in mammals, differing from each other at 10 positions. beta IVa is brain specific, whereas beta IVb is ubiquitous, and both appear to be constitutive. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis, organellar and flagellar movement, intracellular transport, and cytoskeletal functions.

Database

Research Area

REFERENCE

Application Reference

Thomas SN et al. iScience 2023; 26 (8) : 107361 Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection.
Clifton C et al. Front Cell Infect Microbiol 2022; 12 : 1035566 BPIFA1 is a secreted biomarker of differentiating human airway epithelium.
Brian F Niemeyer et al. Nano Sel 2021; Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia.
Application : ICC/IF
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Package List Price ($)
$ 399