GeneTex
United States (US)

c-Abl antibody

c-Abl-antibody-GTX15130-IHC-1_18121409_525.jpg
c-Abl-antibody-GTX15130-IHC-2_18121409_544.jpg

Cat No. GTX15130

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, IP, IHC
Reactivity Human, Mouse
APPLICATION

Application Note

IHC-P: Use at a dilution of 1/50 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 122.9 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

123 kDa. ( Note )

Positive Control

Placenta
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4 containing 1% BSA and 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Abl Proto-Oncogene 1, Non-Receptor Tyrosine Kinase,Abl,Chdskm,Jtk7,Bcr/Abl,C-Abl,C-Abl1,P150,V-Abl,Abl1

Cellular Localization

Cytoplasmic and Nuclear

Background

The c-Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Database

Research Area

DATA IMAGES
c-Abl-antibody-GTX15130-IHC-1_18121409_525.jpg

GTX15130 IHC Image


c-Abl-antibody-GTX15130-IHC-2_18121409_544.jpg

GTX15130 IHC-P Image

GTX15130 staining c-Abl in human placenta by Immunohistochemistry (FFPE-sections).

Package List Price ($)
$ 319