c-Abl antibody

Cat. No. GTX15130

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, IP, IHC
Reactivity	Human, Mouse
Package	500 μl ($399)

See all c-Abl products

Datasheet
Document

View product citations for antibody GTX15130 on CiteAb

APPLICATION

Application Note

IHC-P: Use at a dilution of 1/50 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 122.9 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

123 kDa. ( Note )

Positive Control

Placenta

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ABL proto-oncogene 1, non-receptor tyrosine kinase , ABL , CHDSKM , JTK7 , bcr/abl , c-ABL , c-ABL1 , p150 , v-abl

Cellular Localization

Cytoplasm, cytoskeleton , Nucleus , Mitochondrion

Background

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Database

Gene ID: 25 ABL1
UniProt: P00519 ABL1

Research Area

DATA IMAGES

GTX15130 IHC-P Image

GTX15130 staining c-Abl in human placenta by Immunohistochemistry (FFPE-sections).

GTX15130 IHC Image

REFERENCE

There are currently no references for c-Abl antibody (GTX15130). Be the first to share your publications with this product.

Submit a Reference

REVIEW

There are currently no reviews for c-Abl antibody (GTX15130). Be the first to share your experience with this product.

Submit a Review

SDS
Sodium Azide.pdf

Package

List Price ($)

500 μl

$ 399

Qty