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c-Fos antibody [2G9C3]

Cat. No. GTX16902

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2G9C3

Isotype

 IgG2a

Application

 WB, ICC/IF

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
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APPLICATION

Application Note

Not suitable for IHC frozen or parraffin-embedded sections. For ICC: Use at a concentration of 2.5 - 5.0 μg/ml. For WB: Use at a concentration of 2.5 - 5.0 μg/ml. Detects bands of approximately 55 and 62 kDa. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

41 kDa. ( Note )

Positive Control

HeLa cells

Product Note

Reacts with both cellular and viral forms, will detect both the 55 kDa and 62 kDa c-fos and v-fos proteins, but does not react with the 39 kDa jun protein.

PROPERTIES

Form

Liquid

Buffer

50mM Sodium Phosphate, 0.2% Gelatin

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: KVEQLSPEEEEKRRIRRERNKMAAA, corresponding to Internal sequence amino acids 128 - 152 of Human c-Fos.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Fos proto-oncogene, AP-1 transcription factor subunit , AP-1 , C-FOS , p55

Cellular Localization

Nucleus , Endoplasmic reticulum , Cytoplasm, cytosol

Background

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Wu L et al. Int J Mol Sci 2023; 24 (15) Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Modulates Inflammatory Pain in Mice.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399