GeneTex
United States (US)

c-Jun antibody

c-Jun-antibody-GTX27964-WB-1_18121409_464.jpg

Cat No. GTX27964

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-Fr, IP
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

36 kDa. ( Note )

Positive Control

NIH/3T3

Specificity/Sensitivity

Reacts with c-Jun p39
PROPERTIES

Form

Liquid

Buffer

PBS with 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Synthetic peptide (Mouse) (N terminal).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Jun Proto-Oncogene,Ap-1,Junc,C-Jun,Jun

Cellular Localization

Nuclear

Background

c-Jun (previously known as the Fos-binding protein p39) and c-Fos form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP-1-binding site (1). AP-1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). Fos and Jun proto-oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Fos has a unique role in determining the differentiation and activity of progenitors of the osteoclast lineage (4). A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds, probably from transcriptional deregulation of v-Jun-responsive target genes (7).

Database

Research Area

DATA IMAGES
c-Jun-antibody-GTX27964-WB-1_18121409_464.jpg

GTX27964 WB Image

Western blot analysis of c-Jun p39 expression in Jurkat whole cell lysates.

Package List Price ($)
$ 319