APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:3000 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No Preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr1234 of human c-Met. The exact sequence is proprietary.
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
MET proto-oncogene, receptor tyrosine kinase , AUTS9 , DFNB97 , HGFR , RCCP2 , c-Met
Cellular Localization
Membrane; Single-pass type I membrane protein,Secreted
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Database
Research Area
DATA IMAGES
![Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244](/templates/default/js/lightbox/images/loading.gif "Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244")
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GTX640244 WB Image
Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with c-Met (phospho Tyr1234) antibody [HL2907] (GTX640244) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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REFERENCE
There are currently no references for c-Met (phospho Tyr1234) antibody [HL2907] (GTX640244). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for c-Met (phospho Tyr1234) antibody [HL2907] (GTX640244). Be the first to share your experience with this product.
![Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244](/upload/website/prouct_img/small/GTX640244/GTX640244_T-45376_20240419_WB_treatment_HGF_24042400_630.webp "Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244")
![Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244](/upload/website/prouct_img/normal/GTX640244/GTX640244_T-45376_20240419_WB_treatment_HGF_24042400_630.webp "Anti-c-Met (phospho Tyr1234) antibody [HL2907] used in Western Blot (WB). GTX640244")