GeneTex

  • Country / Location Selection

United States (US)

c-Myc antibody [33]

Cat. No. GTX17356

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 33

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat, Bird
Package
100 μg ($489)
See all c-Myc products

APPLICATION

Application Note

IF: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. Myc is a labile protein, thereforepreotease inhibitors should be used at all times. IP (with and without SDS): Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 49, 64 & 67 kD (predicted molecular weight: 49 kD). 64 and 67kD forms are phosphophorylated. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

49 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification

IgG fraction

Conjugation

Unconjugated

RRID

AB_425144

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

MYC proto-oncogene, bHLH transcription factor , MRTL , MYCC , bHLHe39 , c-Myc

Cellular Localization

nucleoplasm , Nucleolus

Background

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Database

Research Area

REFERENCE

Application Reference

SH Chen et al. Neurotherapeutics 2024; 21 (3) : e00336 Ultrahigh frequency transcutaneous electrical nerve stimulation for neuropathic pain alleviation and neuromodulation
Application : IHC-Fr
Liao CJ et al. BMC Cancer 2014; 14 : 555 Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for c-Myc antibody [33] (GTX17356). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 489