GeneTex

  • Country / Location Selection

United States (US)

c-Myc antibody [JAC6]

Cat. No. GTX10910

Reference 4

Host

 Rat

Clonality

 Monoclonal

Clone Name

 JAC6

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP

Reactivity

 Human, Wheat
Package
50 μg ($399)
See all c-Myc products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/500-1/1,000
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

Product Note

This antibody recognizes the sequence EQKLISEEDL.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 408-439 corresponding to the C-terminal region of human c-myc

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_368675

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

MYC proto-oncogene, bHLH transcription factor , MRTL , MYCC , bHLHe39 , c-Myc

Cellular Localization

nucleoplasm , Nucleolus

Background

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Database

Research Area

REFERENCE

Application Reference

Kiko Hasegawa et al. Int J Mol Sci 2021; 22 (19) Atrophy of White Adipose Tissue Accompanied with Decreased Insulin-Stimulated Glucose Uptake in Mice Lacking the Small GTPase Rac1 Specifically in Adipocytes.
Application : IHC-P
Takenaka N et al. Int J Mol Sci 2019; 20 (21) A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes.
Hurni S et al. Plant J 2014; Powdery mildew resistance gene Pm8 derived from rye is suppressed by its wheat ortholog Pm3.
Application : WB
Reactivity : Wheat
Yang L et al. J Biol Chem 2008; 283 (17) : 11823-31 The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin.
Application : ICC/IF
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for c-Myc antibody [JAC6] (GTX10910). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399