GeneTex
United States (US)

delta Opioid receptor antibody

Cat No. GTX10272

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application ICC/IF
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

ICC: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user. NOT recommended for tissue section staining. For studies of neuronal tissue, use GTX10271.

Calculated MW

40 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.05% Sodium Azide; Constituents: Whole Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Synthetic peptide: TACTPSDGPGGGAAA, corresponding to amino acids 358-372 of Rat Delta Opioid Receptor.

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Opioid Receptor, Delta 1,Oprd1

Background

This protein functions as an inhibitor for neurotransmittors release by reducing calcium ion currents and increasing potassium ion conductance. Jordan and Devi (1999) provided biochemical and pharmacologic evidence for the heterodimerization of 2 fully functional opioid receptors, kappa (OPRK1; 165196) and delta. This results in a new receptor that exhibits ligand binding and functional properties that are distinct from those of either receptor. Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Pharmacologic and electrophysiologic evidence indicates that opioid receptors are involved in the mechanism of heroin dependence. Thus, opioid receptors are appropriate candidate genes for case-control association studies of heroin dependence Xu et al. (2002).

Database

Research Area

Package List Price ($)
$ 319