eIF2 alpha (phospho Ser48) antibody

Cat. No. GTX79089

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human
Package	100 μg ($399)

See all eIF2 alpha products

Datasheet

View product citations for antibody GTX79089 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human eIF2a around the phosphorylation site of Serine 49 (L-L-Sp-E-L).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11167406

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

EIF2,EIF2A,EIF2S1,EIF2alpha,eukaryotic translation initiation factor 2 subunit alpha,eIF2 alpha

Cellular Localization

Cytoplasmic granule

Background

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Database

Gene ID: 1965 EIF2S1
UniProt: P05198 EIF2S1

Research Area

DATA IMAGES

GTX79089 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79089 eIF2 alpha (phospho Ser48) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty