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gamma Catenin antibody [CTNG/1664]

Anti-gamma Catenin antibody [CTNG/1664] used in IHC (Paraffin sections) (IHC-P). GTX34752
Anti-gamma Catenin antibody [CTNG/1664] used in IHC (Paraffin sections) (IHC-P). GTX34752

Cat No. GTX34752

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CTNG/1664

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human
Package
100 μg ($429)
See all gamma Catenin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1.0ug/ml
ICC/IF 1-2ug/ml
IHC-P 0.1-0.2ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes
Not tested in other applications.

Calculated MW

82 kDa. ( Note )

Specificity/Sensitivity

It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (α, β, γ and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. α T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. α T-catenin binds to α E-catenin as well as to β-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for α-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human full-length gamma catenin protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Junction Plakoglobin , Ctnng , Dp3 , Dpiii , Pdgb , Pkgb , Jup

Background

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-gamma Catenin antibody [CTNG/1664] used in IHC (Paraffin sections) (IHC-P). GTX34752

GTX34752 IHC-P Image

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Catenin, gamma Monoclonal Antibody (CTNG/1664)

Anti-gamma Catenin antibody [CTNG/1664] used in IHC (Paraffin sections) (IHC-P). GTX34752

GTX34752 IHC-P Image

Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Catenin, gamma Monoclonal Antibody (CTNG/1664)

REFERENCE

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REVIEW

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Package List Price ($)
$ 429