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hnRNP A1 antibody [9H10]

Cat. No. GTX80389

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 9H10

Isotype

 IgG2b

Application

 WB, ICC/IF, IP, ELISA

Reactivity

 Human
Package
50 μl ($319)
See all hnRNP A1 products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:2000-1:4000
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

39 kDa. ( Note )

Product Note

Human hnRNP-A1. Detects a band of approximately 34 kDa

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length hnRNP-A1 native protein (partially purified) from HeLa cells (human)

Purification

Protein A

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

heterogeneous nuclear ribonucleoprotein A1 , ALS19 , ALS20 , HNRPA1 , HNRPA1L3 , IBMPFD3 , UP 1 , hnRNP A1 , hnRNP-A1

Cellular Localization

Nucleus , Cytoplasm

Background

This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]

Database

Research Area

REFERENCE

Clone Reference

Sareen D et al. Sci Transl Med 2013; 5 (208):208ra149 Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.
Fuentealba RA et al. J Biol Chem 2010; 285 (34):26304-14 Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319