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iC3b (neoantigen) antibody [013III-1.16]

Cat. No. GTX40522

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 013III-1.16

Isotype

 IgG2b

Application

 WB, IHC-Fr, FACS, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($759)
See all C3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

187 kDa. ( Note )

Product Note

This antibody recognizes the ~42kDa human inactive complement component 3b (iC3b) neoantigen present in blood serum.

PROPERTIES

Form

Liquid

Buffer

Borate buffered saline

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human iC3b

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_11174243

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C3 , AHUS5 , ARMD9 , ASP , C3a , C3b , CPAMD1 , HEL-S-62p

Cellular Localization

Secreted

Background

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Database

Research Area

REFERENCE

Application Reference

Jaumouill矇 V et al. Nat Cell Biol 2019; 21 (11) : 1357-1369 Coupling of 帣2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.
Reactivity : Mouse
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 759