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mGluR2 antibody

Anti-mGluR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13192

Cat No. GTX13192

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P
Reactivity Human
Package
25 μg ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P 5 - 10 μg/ml
Not tested in other applications.

Calculated MW

95.57 kDa. ( Note )

Predict Reactivity

Mouse, Rat, Rabbit, Bovine, Dog, Hamster, Pig, Monkey, Bat, Chimpanzee, Elephant, Gibbon, Gorilla, Horse, Marmoset, Panda, Platypus(>80% identity)
PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 19 amino acid peptide from N-terminal extracellular domain of human mGluR2.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

GLUR2,GPRC1B,GRM2,MGLUR2,glutamate metabotropic receptor 2,mGlu2,Metabotropic Glutamate Receptor 2,

Cellular Localization

Cell membrane,Cell junction,Synapse,Cell projection,Dendrite

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

Database

Research Area

DATA IMAGES
Anti-mGluR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13192

GTX13192 IHC-P Image

IHC-P analysis of human brain tissue (neurons and glia) using GTX13192 mGluR2 antibody.
Antigen retrival : Heat-induced antigen retrieval

REFERENCE
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Package List Price ($)
$ 319