GeneTex
United States (US)

mGluR2 + mGluR3 antibody

GTX31056_598_IHC-P_18121410_391.jpg
GTX31056_1523_WB_18121410_528.jpg
GTX31056_599_IHC-P_18121410_417.jpg
GTX31056_1522_WB_18121410_881.jpg

Cat No. GTX31056

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:50 - 1:200
ELISA Assay dependent
IHC 1:50 - 1:200
Not tested in other applications.
PROPERTIES

Form

Liquid

Buffer

PBS pH 7.2, 0.05% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 836-872 of Human mGluR-2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Metabotropic Glutamate receptor 2 /3, GRM2, G protein coupled receptor family C group1 m, 2912 24415, Metabotropic Glutamate receptor2 /3, 291224415, G protein coupled receptor family C group 1 m

Background

The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-2, which may interact with GRASP, acts as a receptor for glutamate. It may also be involved in the regulation of neurotransmission suppression and in synaptogenesis or synaptic stablization. mGluR-3,which may interact with GRASP, acts as a receptor for glutamate.

Research Area

DATA IMAGES
GTX31056_598_IHC-P_18121410_391.jpg

GTX31056 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX31056 mGluR2 + mGluR3 antibody.
Dilution : 1:50

GTX31056_1523_WB_18121410_528.jpg

GTX31056 WB Image

WB analysis of mouse brain tissue lysate using GTX31056 mGluR2 + mGluR3 antibody.

GTX31056_599_IHC-P_18121410_417.jpg

GTX31056 IHC-P Image

IHC-P analysis of human brain tissue using GTX31056 mGluR2 + mGluR3 antibody.

GTX31056_1522_WB_18121410_881.jpg

GTX31056 WB Image

WB analysis of multiple samples using GTX31056 mGluR2 + mGluR3 antibody.
Lane1 : HEK293T
Lane2 : Mouse brain tissue
Lane3 : PC12
Dilution : 1:500

Package List Price ($)
$ 319