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mGluR2 + mGluR3 antibody

Anti-mGluR2 + mGluR3 antibody used in Western Blot (WB). GTX78272
Anti-mGluR2 + mGluR3 antibody used in Immunohistochemistry (IHC). GTX78272

Cat. No. GTX78272

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC

Reactivity

 Rat
Package
100 μg ($399)
See all mGluR2 + mGluR3 products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:500 dilution
For ICC/IF: Use at 1:250
For IHC: Use at 1:250
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.

Product Note

Reacts with residues 860-872 [NGREVVDSTTSSL] of the rat mGlurR2/3 protein. Sequence is 100% conserved between mGluR2 and mGluR3. Predicted react to human and mouse.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Purification

Affinity purified

Conjugation

Unconjugated

RRID

AB_625960

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Metabotropic glutamate receptor

Background

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.

Research Area

DATA IMAGES

Anti-mGluR2 + mGluR3 antibody used in Western Blot (WB). GTX78272

GTX78272 WB Image

Western Blot analysis of rat brain showing bands migrating at ~100 kDa and ~190 kDa (which may be a dimer of the smaller band).

Anti-mGluR2 + mGluR3 antibody used in Immunohistochemistry (IHC). GTX78272

GTX78272 IHC Image

mGluR2/3 polyclonal antibody (1:250 dilution) was used on perfusion-fixed tissue from rat spinal cord.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399