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mGluR3 antibody

Cat No. GTX10309

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human, Mouse, Rat
Package
100 μl ($319)

APPLICATION

Application Note

WB: Use at a dilution of 1/1000. Predicted molecular weight: 105.2 kDa. GTX10309 has only been shown to work by Western blot in systems using highly expressing transfected cells using standard protocols. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

99 kDa. ( Note )

Positive Control

Rat Cerebellar and cortical Membrane

PROPERTIES

Form

Liquid

Buffer

Preservative: 0.1% Sodium Azide; Constituents: 1.0% BSA, Tris-glycine. pH 7.8

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Synthetic peptide: TKVDEAEYM, corresponding to amino acids 118-126 of Rat mGluR3.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Glutamate Metabotropic Receptor 3 , Mglur3 , Grm3

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf