APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 7 - 18 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Chicken, Baboon, Chimpanzee, Marmoset, Opossum, Shrew, Xenopus, Platypus, Stickleback, Armadillo, Galago(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.79 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 19 amino acid peptide from C-terminus of human GRM8 / MGLUR8.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375495
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glutamate metabotropic receptor 8 , GLUR8 , GPRC1H , GRM8 , MGLUR8 , mGlu8 , mGluR8 , Metabotropic Glutamate Receptor 8
Cellular Localization
Cell membrane
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
|
GTX71001 IHC-P Image
IHC-P analysis of human brain, neurons and glia tissue using GTX71001 mGluR8 antibody.
Antigen retrieval : Heat-induced antigen retrieval
|
|
|
GTX71001 IHC-P Image
IHC-P analysis of brain, medulla tissue using GTX71001 mGluR8 antibody.
|
|
|
GTX71001 IHC-P Image
IHC-P analysis of human pancreas, carcinoma tissue using GTX71001 mGluR8 antibody.
Antigen retrieval : Heat-induced antigen retrieval
|
REFERENCE
There are currently no references for mGluR8 antibody (GTX71001). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for mGluR8 antibody (GTX71001). Be the first to share your experience with this product.
