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p107 peptide

Cat. No. GTX22452

Application

 IP

Species

 Human
Package
500 μl ($179)
See all p107 products

APPLICATION

Application Note

Blocking peptide for rabbit polyconal antibody to p107(GTX22451).

Calculated MW

121 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, BSA

Preservative

0.1% Sodium azide

Storage

Store this product at 4ºC, DO NOT FREEZE. The product is stable for one year from the date of shipment.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Peptide mapping to the carboxy terminal domain of human p107.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

RB transcriptional corepressor like 1 , CP107 , PRB1 , p107

Cellular Localization

Nucleus

Background

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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Package List Price ($)
$ 179