*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
The peptide used to generate this antibody is available for purchase (GTX88429-PEP).
This antibody is expected to recognize the pancreas isoform (NP_478104.1) only.
Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.
Peptide with sequence C-ILRKKGRLPGEFSE, from the internal region of the protein sequence according to NP_478104.1.
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
INK4 Antibody , P16INK4A Antibody , CMM2 Antibody , P19 Antibody , P14ARF Antibody , CDKN2A Antibody , P14 Antibody , MTS1 Antibody , CDK4I Antibody , P19ARF Antibody , TP16 Antibody , ARF Antibody , MLM Antibody , P16 Antibody , P16INK4 Antibody , INK4A Antibody , CDKN2 Antibody
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]