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p15 INK4b antibody [DCS114.1]

Cat. No. GTX75687

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DCS114.1

Isotype

 IgG1

Application

 WB, IHC-Fr, IP, IHC

Reactivity

 Human
Package
50 μg ($409)
See all p15 INK4b products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

15 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length recombinant p15 His tagged

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_376967

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin dependent kinase inhibitor 2B , CDK4I , INK4B , MTS2 , P15 , TP15 , p15INK4b

Cellular Localization

Cytoplasm

Background

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Itoh M et al. Oncotarget 2017; 8 (54) : 92157-92170 The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells.
Application : WB
Reactivity : Human
Sakellariou S et al. Anticancer Res 2008; 28 (2A) : 1079-83 Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer.
Application : IHC
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409