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p21 Cip1 antibody [4D10]

Anti-p21 Cip1 antibody [4D10] used in IHC (Paraffin sections) (IHC-P). GTX01859

Cat. No. GTX01859

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4D10

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($629)
See all p21 Cip1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:20–1:40

Note :

IHC-P
High temperature antigen unmasking technique. Standard ABC technique.
Not tested in other applications.

Calculated MW

18 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Prokaryotic recombinant fusion protein corresponding to the full length WAF1 molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin dependent kinase inhibitor 1A , CAP20 , CDKN1 , CIP1 , MDA-6 , P21 , SDI1 , WAF1 , p21CIP1

Cellular Localization

Cytoplasm , Nucleus

Background

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-p21 Cip1 antibody [4D10] used in IHC (Paraffin sections) (IHC-P). GTX01859

GTX01859 IHC-P Image

IHC-P analysis of squamous cell carcinoma tissue using GTX01859 p21 Cip1 antibody [4D10].

REFERENCE

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REVIEW

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Package List Price ($)
$ 629