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p21 Cip1 antibody [WA-1]

Anti-p21 Cip1 antibody [WA-1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX27903
Anti-p21 Cip1 antibody [WA-1] used in IHC (Paraffin sections) (IHC-P). GTX27903

Cat. No. GTX27903

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 WA-1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, ELISA

Reactivity

 Human, Primate
Package
100 μg ($339)
See all p21 Cip1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

18 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human p21 protein

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CAP20 , CDKN1 , CDKN1A , CIP1 , MDA6 , P21 , SDI1 , WAF1 , cyclin dependent kinase inhibitor 1A , p21CIP1 , p21 , p21 Cip1

Cellular Localization

Cytoplasm,Nucleus

Background

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-p21 Cip1 antibody [WA-1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX27903

GTX27903 ICC/IF Image

ICC/IF analysis of human primary fibroblasts using GTX27903 p21 Cip1 antibody [WA-1].
Green : Primary antibody
Red : Actin
Blue : DAPI

Anti-p21 Cip1 antibody [WA-1] used in IHC (Paraffin sections) (IHC-P). GTX27903

GTX27903 IHC-P Image

IHC-P analysis of colon carcinoma tissue using GTX27903 p21 Cip1 antibody [WA-1].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339