APPLICATION
Application Note
Blocking peptide for rabbit polyconal antibody to p21 Cip1(GTX27960).
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, BSA
Preservative
0.1% Sodium azide
Storage
Keep as concentrated solution, aliquot and store at 4ºC.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Region/Sequence
Peptide mapping to the carboxy terminus of human p21.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
cyclin dependent kinase inhibitor 1A , CAP20 , CDKN1 , CIP1 , MDA-6 , P21 , SDI1 , WAF1 , p21CIP1
Cellular Localization
Cytoplasm , Nucleus
Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
Database
Research Area
REFERENCE
There are currently no references for p21 peptide (GTX28015). Be the first to share your publications with this product.
REVIEW
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