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p27 Kip1 antibody

Anti-p27 Kip1 antibody used in Immunohistochemistry (IHC). GTX27961

Cat. No. GTX27961

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP, IHC

Reactivity

 Human, Mouse, Rat, Sheep
Package
1 ml ($399)
See all p27 Kip1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:200
IP Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

22 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX28016).

PROPERTIES

Form

Liquid

Buffer

PBS, 0.2% Gelatin

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide mapping to the carboxy terminus of human p27.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_369312

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin dependent kinase inhibitor 1B , CDKN4 , KIP1 , MEN1B , MEN4 , P27KIP1

Cellular Localization

Nucleus , Cytoplasm , Endosome

Background

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Database

Research Area

DATA IMAGES

Anti-p27 Kip1 antibody used in Immunohistochemistry (IHC). GTX27961

GTX27961 IHC Image

The data was published in the journal Mol Cell Endocrinol in 2013.PMID: 23791816

REFERENCE

Application Reference

Rashno Z et al. Sci Rep 2023; 13 (1) : 11465 Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity.
Bellingham M et al. Mol Cell Endocrinol 2013; 376 (43102) : 156-72 Exposure to chemical cocktails before or after conception--- the effect of timing on ovarian development.
Chen YJ et al. Cancer Lett 2012; 319 (2) : 223-31 Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-stimulated breast cancer cells proliferation.
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Package List Price ($)
$ 399