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p38 MAPK antibody [RM245]

Anti-p38 MAPK antibody [RM245] used in IHC (Paraffin sections) (IHC-P). GTX33621
Anti-p38 MAPK antibody [RM245] used in Western Blot (WB). GTX33621

Cat No. GTX33621

Host Rabbit
Clonality Monoclonal
Clone Name RM245
Isotype IgG
Application WB, IHC-P
Reactivity Human
Package
100 μl ($319)
APPLICATION

Application Note

Immunohistochemistry (IHC): 1:1000-1:5000 dilution, Western Blot (WB): 1:1000-1:2000 dilution.

Calculated MW

41 kDa. ( Note )

Specificity/Sensitivity

This antibody reacts to human p38 MAPK. This antibody may also react to rat and mouse p38 MAPK, as predicted by immunogen homology.
PROPERTIES

Form

Liquid

Buffer

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to human p38 MAPK.

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mitogen-Activated Protein Kinase 14 , Csbp , Csbp1 , Csbp2 , Cspb1 , Exip , Mxi2 , Prkm14 , Prkm15 , Rk , Sapk2A , P38 , P38Alpha , Mapk14

Cellular Localization

Cytoplasm , Nucleus

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-p38 MAPK antibody [RM245] used in IHC (Paraffin sections) (IHC-P). GTX33621

GTX33621 IHC-P Image

Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissuesections using Anti-p38 MAPK RM245 at a 1:5000 dilution.

Anti-p38 MAPK antibody [RM245] used in Western Blot (WB). GTX33621

GTX33621 WB Image

Western Blot of HeLa cells lysates using Anti-p38 MAPK RM245 at a 1:1000 dilution, showed a band of p38 MAPK (~38 kDa) expressed in HeLa cells.

REFERENCE
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REVIEW
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Package List Price ($)
$ 319