GeneTex
United States (US)

p53 (acetyl Lys373) antibody

Cat No. GTX30768

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

For WB: Use at a dilution of 1:1,000-1:5,000. Detects GST-p53 acetylated by recombinant p300, HAT domain in an in vitro acetyl transferase assay. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

44 kDa. ( Note )

Specificity/Sensitivity

Detects GST-p53 acetylated by recombinant p300, HAT domain in an in vitro acetyl transferase assay.
PROPERTIES

Form

Liquid

Buffer

Whole antiserum containing 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

whole antiserum

Antigen Species

Human

Immunogen

Synthetic peptide - amino acids 367-379 of human p53 (SHLKSK[AcK]GQSTSR)

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tumor Protein P53,Bcc7,Lfs1,P53,Trp53,Tp53

Background

p53 tumor suppressor gene mutations are one of the most common genetic alterations in human tumors, including lymphomas. Altering or inactivating p53 by mutation or reaction with oncogenes or viruses may cause depletion of p53, or conversion of p53 from a tumor suppressor gene to a transforming oncogene. The nuclear protein p53 is associated with cell transformation and proliferation, with definitive possibilities as a marker in malignant lymphoma progression. p53's role in the multistep process leading to cancer is still being investigated, with an emphasis on its relation and control over additional tumor suppressors.

Database

Research Area

Package List Price ($)
$ 319