p53 (acetyl Lys386) antibody

Cat. No. GTX88009

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	ICC/IF, IHC-P
Reactivity	Human
Package	100 μg ($399)

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Datasheet
Document

View product citations for antibody GTX88009 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
ICC/IF	1:100~1:500
IHC-P	1:50~1:100

Not tested in other applications.

Calculated MW

44 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human p53 (344-393).

Purification

Purified by antigen-affinity chromatography. Non-acetylated peptide was removed by chromatography using corresponding non-acetylated peptide.
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BCC7 , LFS1 , P53 , TP53 , TRP53 , tumor protein p53 , p53

Cellular Localization

Cytoplasm,Nucleus,Nucleus,PML body,Endoplasmic reticulum,Mitochondrion matrix,Nucleus,Cytoplasm,Nucleus,Cytoplasm,Nucleus,Cytoplasm,Nucleus,Cytoplasm,Nucleus,Cytoplasm,Nucleus,Cytoplasm,Cytoplasm

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Database

Gene ID: 7157 TP53
UniProt: P04637 TP53

Research Area

DATA IMAGES

GTX88009 IHC-P Image

IHC-P analysis of human lung carcinoma tissue using GTX88009 p53 (acetyl Lys386) antibody. The picture on the right is blocked with the synthesized peptide.

GTX88009 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX88009 p53 (acetyl Lys386) antibody. The picture on the right is blocked with the synthesized peptide.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μg

$ 399

Qty