PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
0.5mg/ml(Please refer to the vial label for the specific concentration.)
Synthetic peptide: GDPERPEAAGLDQDER, corresponding to amino acids 2-17 of Human p53R2.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Ribonucleotide Reductase Regulatory Tp53 Inducible Subunit M2B,Mtdps8A,Mtdps8B,P53R2,Rrm2B
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 (1), Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). P53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73also induces p53R2 expression (8). p53R2 is an important target of p53 for tumor suppression.