GeneTex
United States (US)

p53R2 antibody

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Cat No. GTX28105

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

This antibody can be used for detection of p53R2 byWestern blot at 0.5 to 1 μg/ml and a 39 kDa band can bedetected.

Calculated MW

41 kDa. ( Note )

Positive Control

A431 or 3T3 cell lysate
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: GDPERPEAAGLDQDER, corresponding to amino acids 2-17 of Human p53R2.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Ribonucleotide Reductase Regulatory Tp53 Inducible Subunit M2B,Mtdps8A,Mtdps8B,P53R2,Rrm2B

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 (1), Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). P53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73also induces p53R2 expression (8). p53R2 is an important target of p53 for tumor suppression.

Database

Research Area

DATA IMAGES
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GTX28105 WB Image