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p57 Kip2 antibody [25B2]

Anti-p57 Kip2 antibody [25B2] used in IHC (Paraffin sections) (IHC-P). GTX01862

Cat. No. GTX01862

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 25B2

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human
Package
500 μl ($639)
See all p57 Kip2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin dependent kinase inhibitor 1C , BWCR , BWS , KIP2 , WBS , p57 , p57Kip2

Cellular Localization

Nucleus

Background

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Database

Research Area

DATA IMAGES

Anti-p57 Kip2 antibody [25B2] used in IHC (Paraffin sections) (IHC-P). GTX01862

GTX01862 IHC-P Image

IHC-P analysis of human placenta tissue using GTX01862 p57 Kip2 antibody [25B2]. Note nuclear staining for cytotrophoblast and stromal cells of the villi.

REFERENCE

Application Reference

Chang MC et al. Int Endod J 2021; (Epub) Effect of butyrate, a bacterial by-product, on the viability and ICAM-1 expression/production of human vascular endothelial cells: Role in infectious pulpal/periapical diseases.
Application : WB
Reactivity : Human
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Package List Price ($)
$ 639