GeneTex
United States (US)

p62Dok antibody

Cat No. GTX28112

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

For WB: Use at a dilution of 1:1,000-1:2,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

52 kDa. ( Note )

Positive Control

Jurkat whole cell lysate
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide -amino acids 425-439 of Human p62Dok.

Purification

Affinity purified with antigen

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

MGC117395, MGC138860, P62DOK

Background

Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories (1,2). Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP) (1-3). p62dok represents a new family with very recently identified p56dok (4).

Database

Research Area

Package List Price ($)
$ 329