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p63 antibody [TP40/3980R] (Biotin)

Anti-p63 antibody [TP40/3980R] (Biotin) used in IHC (Paraffin sections) (IHC-P). GTX02731

Cat. No. GTX02731

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 TP40/3980R

Isotype

 IgG

Application

 ICC/IF, IHC-P, FACS

Reactivity

 Human
Package
500 μl ($529)
See all p63 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 2-4 μg/ml
IHC-P 2-4 μg/ml
FACS 2-4 μg/million cells

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

77 kDa. ( Note )

Product Note

This antibody is specific for delta-Np63 (DNp63) isoform.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from the N-terminal of human p40 protein

Purification

Protein A purified

Conjugation

Biotin

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor protein p63 , AIS , B(p51A) , B(p51B) , EEC3 , KET , LMS , NBP , OFC8 , RHS , SHFM4 , TP53CP , TP53L , TP73L , p40 , p51 , p53CP , p63 , p73H , p73L

Cellular Localization

Nucleus

Background

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

Database

Research Area

DATA IMAGES

Anti-p63 antibody [TP40/3980R] (Biotin) used in IHC (Paraffin sections) (IHC-P). GTX02731

GTX02731 IHC-P Image

IHC-P analysis of human prostate tissue section using GTX02731 p63 antibody [TP40/3980R] (Biotin).

REFERENCE

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REVIEW

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Package List Price ($)
$ 529