GeneTex
United States (US)

p75 NGF Receptor / CD271 antibody [NTR/912]

GTX34947_20170712_IHC-P_1_18121410_722.jpg
GTX34947_20170712_IHC-P_18121410_578.jpg

Cat No. GTX34947

Host Mouse
Clonality Monoclonal
Clone Name NTR/912
Isotype IgG1
Application IHC-P
Reactivity Human, Primate
APPLICATION

Application Note

IHC-P:0.5-1ug/ml for 30 minutes at RT.

Calculated MW

45 kDa. ( Note )

Specificity/Sensitivity

It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human p75 NGFR protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Nerve Growth Factor Receptor,Cd271,Gp80-Lngfr,Tnfrsf16,P75(Ntr),P75Ntr,Ngfr

Background

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34947_20170712_IHC-P_1_18121410_722.jpg

GTX34947 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Monoclonal Antibody (NTR/912).

GTX34947_20170712_IHC-P_18121410_578.jpg

GTX34947 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Monoclonal Antibody (NTR/912).

Package List Price ($)
$ 329