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tPA antibody [629-2A1-53]

Cat. No. GTX79604

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 629-2A1-53

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Pig
Package
500 μg ($399)
See all tPA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Product Note

Recognises heavy chain of Tissue Plasminogen Activator (tPA)

PROPERTIES

Form

Liquid

Buffer

50mM Sodium Phosphate, 100mM NaCl, 1mM EDTA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

10 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length wild-type human protein (Glycosylated).

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_11169716

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

PLAT,TPA,plasminogen activator, tissue type,tPA,TPA Tissue Plasminogen Activator

Cellular Localization

Secreted,Extracellular space

Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399