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tPA antibody [HL2585]

Recombinant antibody
Anti-tPA antibody [HL2585] used in IHC (Paraffin sections) (IHC-P). GTX639036
Anti-tPA antibody [HL2585] used in IHC (Paraffin sections) (IHC-P). GTX639036
Anti-tPA antibody [HL2585] used in Western Blot (WB). GTX639036

Cat. No. GTX639036

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HL2585

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all tPA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human tPA.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

plasminogen activator, tissue type , T-PA , TPA

Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-tPA antibody [HL2585] used in IHC (Paraffin sections) (IHC-P). GTX639036

GTX639036 IHC-P Image

tPA antibody [HL2585] detects secreted tPA protein by immunohistochemical analysis.
Sample: Paraffin-embedded rat thymus gland.
tPA stained by tPA antibody [HL2585] (GTX639036) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-tPA antibody [HL2585] used in IHC (Paraffin sections) (IHC-P). GTX639036

GTX639036 IHC-P Image

tPA antibody [HL2585] detects tPA protein by immunohistochemical analysis.
Sample: Paraffin-embedded mouse tissues.
tPA stained by tPA antibody [HL2585] (GTX639036) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-tPA antibody [HL2585] used in Western Blot (WB). GTX639036

GTX639036 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with tPA antibody [HL2585] (GTX639036) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
$ 169
Custom Conjugations