Jab1 antibody [8H8.5]

Cat. No. GTX70207

Reference 8

Host	Mouse
Clonality	Monoclonal
Clone Name	8H8.5
Isotype	IgG2a
Application	WB, IP
Reactivity	Human, Mouse, Drosophila
Package	100 μl ($399)

See all Jab1 products

Datasheet
Reference

View product citations for antibody GTX70207 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
IP	Assay dependent

Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Positive Control

293 cell lysate

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

The full-length mouse JAB-1 gene expressed in E. coli.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_371982

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

COP9 signalosome subunit 5 , CSN5 , JAB1 , MOV-34 , SGN5

Cellular Localization

Cytoplasm, cytosol , Nucleus

Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Database

Gene ID: 10987 COPS5
UniProt: Q92905 COPS5

Research Area

DATA IMAGES

GTX70207 WB Image

Detection of human Jab1 protein in HeLa whole cell lysate using GeneTex monoclonal antibody GTX70207

GTX70207 WB Image

Part of a customer review using GTX70207

GTX70207 WB Image

Customer Review using GTX70207 - D10 T cells were lysed in IP buffer (20mM Tris-HCl, pH 7.5, 50mM NaCl, 50mM NaF, 10mM -glycerophosphate, 1% Triton X-100, 1mM PMSF).