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PGC1 alpha antibody

Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356
Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356
Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356
Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356

Cat. No. GTX37356

Reference 27

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μg ($459)
See all PGC1 alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:200-1000
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human PGC1 alpha. Please contact us for the exact immunogen sequence.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_11175466

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

PPARG coactivator 1 alpha , LEM6 , PGC-1(alpha) , PGC-1alpha , PGC-1v , PGC1 , PGC1A , PPARGC1

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356

GTX37356 WB Image

WB analysis of rat heart (Lane 1), mouse skeletal muscle (Lane 2), rat testis (Lane 3), mouse colon (Lane 4), rat thymus (Lane 5), mouse liver (Lane 6) tissue lysates using GTX37356 PGC1 alpha antibody.
Dilution : 0.5μg/ml

Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356

GTX37356 WB Image

The data was published in the journal Sci Rep in 2017. PMID: 29215072

Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356

GTX37356 WB Image

The data was published in the 2018 in PeerJ. PMID: 30065891

Anti-PGC1 alpha antibody used in Western Blot (WB). GTX37356

GTX37356 WB Image

The data was published in the journal Reprod Biol Endocrinol in 2018. PMID: 29316934

REFERENCE

Application Reference

Liu W et al. Front Public Health 2024; 12 : 1302175 Effects of short-term exercise and endurance training on skeletal muscle mitochondria damage induced by particular matter, atmospherically relevant artificial PM2.5.
Front Public Health et al. 2023; Effects of short-term exercise and endurance training on skeletal muscle mitochondria damage induced by particular matter, atmospherically relevant artificial PM2.5
Application : WB
Richard J. Bloomer et al. Processes 2023; 11 (7) : 2011 Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts
Application : WB
Liang MZ et al. Cell Biosci 2023; 13 (1) : 96 Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury.
Mesquita PHC et al. bioRxiv 2023; Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training.
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REVIEW

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Application Reference
Liu W et al. Front Public Health 2024; 12:1302175 Effects of short-term exercise and endurance training on skeletal muscle mitochondria damage induced by particular matter, atmospherically relevant artificial PM2.5.
Front Public Health et al. 2023; Effects of short-term exercise and endurance training on skeletal muscle mitochondria damage induced by particular matter, atmospherically relevant artificial PM2.5
Application : WB
Richard J. Bloomer et al. Processes 2023; 11 (7):2011 Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts
Application : WB
Liang MZ et al. Cell Biosci 2023; 13 (1):96 Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury.
Mesquita PHC et al. bioRxiv 2023; Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training.
Wan-Ping Su et al. Biomed Pharmacother 2023; 163 Boosting mitochondrial function and metabolism in aging female germ cells with dual ROCK/ROS inhibition
Application : WB
Reactivity : Human
Mesquita PHC et al. Physiol Rep 2022; 10 (24):e15542 Effects of aging and long-term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats.
Zhang Y et al. Physiol Biochem Zool 2021; 94 (2):71-82 Effects of a Bacterial Infection on Mitochondrial Function and Oxidative Stress in a Songbird.
Application : WB
Mesquita PHC et al. Physiol Rep 2020; 8 (15):e14526 Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.
Application : WB
Reactivity : Human
Shogo Ito et al. PharmaNutrition 2020; 11:100175 Protective effects of nicotinamide mononucleotide against oxidative stress-induced PC12 cell death via mitochondrial enhancement.
Application : WB
Reactivity : Rat
Hill GE et al. Proc Biol Sci 2019; 286 (1911):20191354 Plumage redness signals mitochondrial function in the house finch.
Parry HA et al. Front Physiol 2019; 10:436 Bovine Milk Extracellular Vesicles (EVs) Modification Elicits Skeletal Muscle Growth in Rats.
Garnham JO et al. J Cachexia Sarcopenia Muscle 2019; (Epub) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.
Application : WB
Reactivity : Human
Geoffrey E. Hill et al. bioRxiv 2019; (Epub) Plumage redness signals mitochondrial function in the House Finch.
Application : WB
Hyatt HW et al. Reprod Biol Endocrinol 2018; 16 (1):2 Physiological, mitochondrial, and oxidative stress differences in the presence or absence of lactation in rats.
Roberts MD et al. PeerJ 2018; 6:e5338 Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training.
Parry HA et al. Heliyon 2018; 4 (11):e00975 Ketogenic diet increases mitochondria volume in the liver and skeletal muscle without altering oxidative stress markers in rats.
Hyatt HW et al. Reprod Sci 2018;:1.93E+15 Changes in Metabolism, Mitochondrial Function, and Oxidative Stress Between Female Rats Under Nonreproductive and 3 Reproductive Conditions.
Application : WB
Reactivity : Rat
Zhang Y et al. J Exp Biol 2018; (Epub) High activity before breeding improves reproductive performance by enhancing mitochondrial function and biogenesis.
Application : WB
Reactivity : Mouse
Sajan MP et al. Cell Signal 2018; 43:62-70 coordinated regulation of hepatic foxo1, pgc-1α and srebp-1c facilitates * action and resistance.
Application : WB
Reactivity : Mouse
Wu LH et al. J Cell Physiol 2017; (Epub) Laminar Shear Stress Promotes Mitochondrial Homeostasis in Endothelial Cells.
Application : WB
Reactivity : Human
Hyatt HW et al. Sci Rep 2017; 7 (1):17118 Lactation has persistent effects on a mother's metabolism and mitochondrial function.
Application : WB
Reactivity : Rat
Zhang Y et al. Am J Physiol Regul Integr Comp Physiol 2017;:ajpregu.00176.2017 A mitohormetic response to pro-oxidant exposure in the house mouse.
Application : WB
Reactivity : Mouse
Ye JH et al. Sci Rep 2016; 6:33102 Pentoxifylline ameliorates non-alcoholic fatty liver disease in hyperglycaemic and dyslipidaemic mice by upregulating fatty acid β-oxidation.
Application : WB
Reactivity : Mouse
Chiang MC et al. Exp Cell Res 2016; 347 (2):322-31 * activation of ampk-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction.
Application : WB
Reactivity : Human
Cheng L et al. Biochem Biophys Res Commun 2016; 477 (4):685-91 CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation.
Application : WB
Reactivity : Human
Chung MM et al. Biochim Biophys Acta 2015; 1852 (5):720-31 the neuroprotective role of * in advanced glycation end product treated human neural stem cells is ampk-dependent.
Application : WB
Reactivity : Human
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459