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Neurofibromin antibody [McNFn27b]

Anti-Neurofibromin antibody [McNFn27b] used in IHC (Paraffin sections) (IHC-P). GTX30209

Cat. No. GTX30209

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 McNFn27b

Isotype

 IgG1

Application

 WB, IHC-P, IP, ELISA

Reactivity

 Human, Mouse, Rat, Guinea pig
Package
50 μl ($399)
See all Neurofibromin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 10 - 20 μg/ml
IP 1:10 - 1:500
ELISA 1:100 - 1:2000
Not tested in other applications.

Calculated MW

319 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A highly conserved N-terminal peptide, corresponding to amino acids 27-41 of human Neurofibromin 1. [UniProt# P21359]

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neurofibromin 1 , NFNS , VRNF , WSS

Cellular Localization

Nucleus,Nucleolus

Background

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Neurofibromin antibody [McNFn27b] used in IHC (Paraffin sections) (IHC-P). GTX30209

GTX30209 IHC-P Image

IHC-P analysis of adult human dorsal root ganglia tissue using GTX30209 Neurofibromin antibody [McNFn27b].

REFERENCE

Clone Reference

Wang Q et al. Cancer Cell 2017; 32 (1):42-56.e6 Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Application : WB
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399