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Dynein Intermediate chain antibody [70.1]

Cat. No. GTX26304

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 70.1

Isotype

 IgM

Application

 WB, ICC/IF, IP, ELISA, EM

Reactivity

 Human, Mouse, Rat, Hamster, Chicken, Frog, Indian Muntjac, Marsupials
Package
100 μl ($399)
See all Dynein Intermediate chain products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500~1:2,000
ICC/IF Assay dependent
IP Assay dependent
ELISA Assay dependent
EM Assay dependent
Not tested in other applications.

Positive Control

chicken brain

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Chicken

Immunogen

cytoplasmic dynein from chicken embryo brain

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_385200

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

dynein axonemal intermediate chain 1

Background

Eukaryotic cells rely on actin and microtubule-based protein ""motors"" to generate intracellular movements (4). These protein ""motors"" contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kD), three intermediate chains (70-125 kD), and at least four light chains (15-25 kD) (5).

Database

Research Area

REFERENCE

Application Reference

Shamoto N et al. Cells 2018; 7 (9) CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.
Application : WB
Reactivity : Mouse
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399