GeneTex
  • Country / Location Selection

United States (US)

Norovirus

Figure 1. The NoV virion
 
Figure 1. The Norovirus (NoV) virion

Human noroviruses (HuNoV) (previously referred to as the Norwalk Virus (NV) or Norwalk-like viruses) are the overwhelming (>95%) cause of epidemic non-bacterial gastroenteritis in the world, accounting for more than 200,000 deaths annually and significant morbidity (1). NoVs spread primarily through the fecal-oral route, which facilitates their spread through children under five years of age, the elderly, the immunocompromised, and tourists. The viral-induced self-limited gastroenteritis generally involves abdominal cramping, watery diarrhea, and vomiting. Though there is at least one vaccine candidate in development, there are no specific antivirals for HuNoVs and thorough handwashing procedures remain the best preventative strategy.

HuNoVs belong to the genus Norovirus of the family Caliciviridae. They are non-enveloped viruses containing a positive-sense, single-stranded genomic RNA of ~7.5-7.7 kb (Figures 1-2). Three open-reading frames (ORFs) encode the six non-structural proteins (NS1/2 to NS7), the main capsid protein VP1, and the minor capsid protein VP2, respectively. There are currently ten genogroups (GI–GX) (further subdivided into 49 genotypes) of NoV specified by the sequences of VP1 and the NS7 polymerase, though only GI (to which NV belongs), GII, and GIV cause acute gastroenteritis in humans (1, 2). The GII.4 genotype is associated with a more severe clinical course, and has spun off six pandemic strains. GII.17 is another highly infectious genotype that has been recently detected. Owing to antigenic shift and drift, new variants with more potent invasive capacity and resistance continue to emerge.

GeneTex is proud to add two new genotype-specific antibodies against HuNoV VP1 to its expanding portfolio of NoV research reagents. These are both recombinant rabbit monoclonal antibodies: Norovirus VP1 antibody [HL1672] (GTX637271) (GII.4-specific) and Norovirus VP1 antibody [HL2177] (GTX638181) (GII.17-specific). Please see the highlighted product images and a complete NoV antibody listing below.

Figure 2. Human NoV genomic organization
 
Figure 2. Human NoV genomic organization
Highlighted Products
Recombinant 
Norovirus VP1 antibody [HL2177] (GTX638181)(GII.17-specific)

Norovirus VP1 antibody [HL2177] (GTX638181) (GII.17-specific)

Recombinant
Norovirus VP1 antibody [HL2177] (GTX638181)(GII.17-specific)

Norovirus VP1 antibody [HL2177] (GTX638181) (GII.17-specific)

Recombinant
Norovirus VP1 antibody [HL1672] (GTX637271) (GII.4-specific)

Norovirus VP1 antibody [HL1672] (GTX637271) (GII.4-specific)

Recombinant
     
Norovirus VP1 antibody (GTX134381) (GII.4-specific)

Norovirus VP1 antibody (GTX134381) (GII.4-specific)

 
Norovirus VP1 antibody (GTX134382) (GII.17-specific)

Norovirus VP1 antibody (GTX134382) (GII.17-specific)

 
Norovirus VP2 antibody (GTX134386)

Norovirus VP2 antibody (GTX134386)

 

Cat. No. Product Name Clonality Applications  
GTX637271 Norovirus VP1 antibody [HL1672] Rec Rb mAb WB Recombinant
GTX638181 Norovirus VP1 antibody [HL2177] Rec Rb mAb WB, ICC/IF Recombinant
GTX134381 Norovirus VP1 antibody Rb pAb WB, IHC-P (cell pellet)  
GTX134382 Norovirus VP1 antibody Rb pAb WB  
GTX134380 Norovirus VP1 antibody Rb pAb WB  
GTX134386 Norovirus VP2 antibody Rb pAb WB  
GTX134383 Norovirus VP2 antibody Rb pAb WB  

 

References:

1.    Viruses. 2022 Dec 16;14(12):2811. doi: 10.3390/v14122811.
2.    Front Immunol. 2020 Jun 16;11:961. doi: 10.3389/fimmu.2020.00961.

 

Literature

Flyer - IVD-related Products

Download the latest version of GeneTex's IVD-related Products flyer.
Literature

Flyer - Cited Antibodies 2024 Q2

Download the latest version of GeneTex's Antibodies for Cited Antibodies 2024 Q2 flyer.
Articles

IVD-related Products and Services

Literature

Flyer-Selected Antibodies for Influenza Virus

Download the latest version of GeneTex's Selected Antibodies for Influenza Virus flyer.
Literature

Flyer-Virology

Download the latest version of GeneTex's Virology flyer.
Literature

Flyer-Lateral Flow Antibody Pairs for Respiratory Infectious Diseases

Download the latest version of GeneTex's Lateral Flow Antibody Pairs for Respiratory Infectious Diseases flyer.
Newsletter
Influenza A and B Virus Recombinant Monoclonal Antibodies

Influenza A and B Virus Recombinant Monoclonal Antibodies

Influenza A and B Virus Recombinant Monoclonal Antibodies
Literature

Flyer-Antibodies for Virology Research

Download the latest version of GeneTex's Antibodies for Virology Research flyer.
Literature
Reagents for Omicron Subvariants Resaerch

Flyer- Reagents for Omicron Subvariants Resaerch

Download the latest version of GeneTex's Reagents for Omicron Subvariants Resaerch flyer.
Literature

Flyer-Total Solutions of Antibodies for SARS CoV-2

Download the latest version of GeneTex's Total Solutions of Antibodies for SARS CoV-2 flyer.
Newsletter

Lateral Flow Assay for Influenza & SARS-CoV-2 Viruses Detection

Influenza A & B Virus Antibodies (IVD grade)
Literature
Brochure - Cited Antibodies

Brochure - Cited Antibodies

Download the latest version of GeneTex's Cited Antibodies brochure.
Literature

Brochure - Antibodies For Virology Research

Download the latest version of GeneTex's Antibodies For Virology Research brochure.
Literature
Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

SARS-CoV-2 (COVID-19) Research Reagents
Literature
Brochure - SARS-CoV-2 (COVID-19) Research

Brochure - SARS-CoV-2 (COVID-19) Research

Download the latest version of GeneTex's SARS-CoV-2 (COVID-19) Research brochure.
Newsletter
GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry

GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry

GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry
Newsletter

Neuropilins Facilitate SARS-CoV-2 Entry into Host Cells

Neuropilins Facilitate SARS-CoV-2 Entry into Host Cells
Articles

The concept of a SARS-CoV-2 / COVID-19 rapid test

A rapid virus antigen test detects SARS-CoV-2 particles in samples by capturing viral antigen between a free labeled antibody and a fixed second antibody that each recognize different regions of the antigen.
Literature

Flyer- Virology Research_DM

Download the latest version of GeneTex's Virology Research flyer.
Articles
SARS-CoV-2 (COVID-19) Spike Variant Recombinant Proteins

SARS-CoV-2 (COVID-19) Spike Variant Recombinant Proteins

Newsletter
SARS-CoV-2 Proteins and Antibodies for Lateral Flow-based Neutralization Assay

SARS-CoV-2 Proteins and Antibodies for Lateral Flow-based Neutralization Assay

for Lateral flow-based Neutralization Assay
Literature
Download the latest version of GeneTex's Zika Virus Research flyer.

Flyer-Zika Virus Research

Download the latest version of GeneTex's Zika Virus Research flyer.
Literature
Selected Antibodies for Influenza Virus

Flyer-Selected Antibodies for Influenza Virus

Download the latest version of GeneTex's Selected Antibodies for Influenza Virus flyer.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Newsletter

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses

In an exciting example of this concept, Diep et al. described the use of a genome-scale CRISPR screen to show that the protein histidine methyltransferase SETD3 is crucial for the replication of multiple human enteroviruses.
Newsletter
HBV

Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.

Is a cure for chronic hepatitis B on the horizon? Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature

Flyer - IVD-related Products

Download the latest version of GeneTex's IVD-related Products flyer.
Literature

Flyer - Cited Antibodies 2024 Q2

Download the latest version of GeneTex's Antibodies for Cited Antibodies 2024 Q2 flyer.
Literature

Flyer-Selected Antibodies for Influenza Virus

Download the latest version of GeneTex's Selected Antibodies for Influenza Virus flyer.
Literature

Flyer-Virology

Download the latest version of GeneTex's Virology flyer.
Literature

Flyer-Lateral Flow Antibody Pairs for Respiratory Infectious Diseases

Download the latest version of GeneTex's Lateral Flow Antibody Pairs for Respiratory Infectious Diseases flyer.
Literature

Flyer-Antibodies for Virology Research

Download the latest version of GeneTex's Antibodies for Virology Research flyer.
Literature
Reagents for Omicron Subvariants Resaerch

Flyer- Reagents for Omicron Subvariants Resaerch

Download the latest version of GeneTex's Reagents for Omicron Subvariants Resaerch flyer.
Literature

Flyer-Total Solutions of Antibodies for SARS CoV-2

Download the latest version of GeneTex's Total Solutions of Antibodies for SARS CoV-2 flyer.
Literature
Brochure - Cited Antibodies

Brochure - Cited Antibodies

Download the latest version of GeneTex's Cited Antibodies brochure.
Literature

Brochure - Antibodies For Virology Research

Download the latest version of GeneTex's Antibodies For Virology Research brochure.
Literature
Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

SARS-CoV-2 (COVID-19) Research Reagents
Literature
Brochure - SARS-CoV-2 (COVID-19) Research

Brochure - SARS-CoV-2 (COVID-19) Research

Download the latest version of GeneTex's SARS-CoV-2 (COVID-19) Research brochure.
Literature

Flyer- Virology Research_DM

Download the latest version of GeneTex's Virology Research flyer.
Literature
Download the latest version of GeneTex's Zika Virus Research flyer.

Flyer-Zika Virus Research

Download the latest version of GeneTex's Zika Virus Research flyer.
Literature
Selected Antibodies for Influenza Virus

Flyer-Selected Antibodies for Influenza Virus

Download the latest version of GeneTex's Selected Antibodies for Influenza Virus flyer.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature

Pamphlet - Antibodies for Virus Research

Download the latest version of GeneTex's antibodies for virus research pamphlet.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.