E3 Ligase UBE3A Detection with GeneTex’s New Recombinant Antibody

Ubiquitination is catalyzed by E1, E2, and E3 enzymes that, respectively, activate, conjugate, and ligate ubiquitin to substrate proteins. UBE3A, also known as E6AP (E6-associated protein), is a multifunctional E3 ubiquitin ligase (1). Aberrant regulation of UBE3A is involved in oncogenesis, neurodevelopmental disorders, and other human diseases. In addition to its ubiquitin ligase activity, UBE3A also functions as a transcriptional coactivator of steroid hormone receptors. Its direct link to Angelman syndrome and other pathological conditions makes UBE3A a focus of intense basic and clinical research.

GeneTex has developed the knockdown-validated recombinant rabbit monoclonal UBE3A antibody [HL1660] (GTX637258) to support ubiquitination and UBE3A research. Please see the data images below and visit our website at www.genetex.com for more information.

 

Highlighted Products UBE3A antibody [HL1660] (GTX637258)

 

Reference:

Mol Biomed. 2021 Jul 30;2(1):23. doi: 10.1186/s43556-021-00043-2.