Adhesion GPCRs

Class B2 G protein-coupled receptors (GPCRs), also known as adhesion GPCRs (aGPCRs), are characterized by large extracellular domains and an autoproteolytic GAIN domain. Their unique structure, and the fact that several aGPCRs are mechanosensors, distinguishes them from other GPCR classes. They play key roles in adhesion, development, the immune response, and cell communication, with their dysfunction linked to inflammation, malignancies, and neurological disease. As such, aGPCRs not only provide insight into fundamental biological mechanisms but also represent promising targets for therapeutic development.

Predicted molecular weights for Full-Length, NTF and CTF

GPS: GPCR proteolytic site
NTF: N-Terminal Fragment

CTF: C-Terminal Fragment

Subfamily	Receptor	Synonyms	UniProtID	Length (a.a.)	GPS (start) (a.a.)	GPS (end) (a.a.)	Autoproteolytic cleavage site (a.a.)	Full Length (kD)	NTF (kD)	CTF (kD)
I	ADGRL1	LPHN1	O94910	1474	802	851	838-839	162.1	93.6	70.0
I	ADGRL2	LPHN2	O95490	1459	788	837	824-825	160.5	92.1	69.9
I	ADGRL3	LPHN3	Q9HAR2	1447	805	854	841-842	159.2	93.9	66.7
I	ADGRL4	ELTD1; ETL	Q9HBW9	690	370	419	406-407	75.9	46.1	31.2
II	ADGRE1	EMR1; F4/80	Q14246	886	550	597	-	97.5	65.7	31.8
II	ADGRE2	EMR2	Q9UHX3	823	482	530	517-518	90.5	58.3	33.7
II	ADGRE3	EMR3	Q9BY15	652	304	351	338-339	71.7	38.6	34.5
II	ADGRE4	EMR4	Q91ZE5 (Mouse)	689	292	339	326-327	75.8	37.3	39.9
II	ADGRE5	CD97	P48960	835	495	543	530-531	91.9	59.7	91.9
III	ADGRA1	GPR123	Q86SQ6	560	-	-	-	61.6	-	-
III	ADGRA2	GPR124	Q96PE1	1338	710	759	-	147.2	83.5	63.7
III	ADGRA3	GPR125	Q8IWK6	1321	701	750	-	145.3	82.5	62.8
IV	ADGRC1	CELSR1	Q9NYQ6	3014	2411	2461	do not undergo cleavage	331.5	-	-
IV	ADGRC2	CELSR2	Q9HCU4	2923	2319	2369	2356-2357	321.5	260.6	62.4
IV	ADGRC3	CELSR3	Q9NYQ7	3312	2480	2530	-	364.3	278.3	86.0
V	ADGRD1	GPR133	Q6QNK2	874	510	557	544-545	96.1	61.3	36.3
V	ADGRD2	GPR144	Q7Z7M1	963	599	649	-	105.9	71.4	34.5
VI	ADGRF1	GPR110	Q5T601	910	534	579	566-567	100.1	63.7	37.8
VI	ADGRF2	GPR111	Q8IZF7	708	394	442	do not undergo cleavage	77.9	-	-
VI	ADGRF3	GPR113	Q8IZF5	1079	715	765	752-753	118.7	84.2	36.0
VI	ADGRF4	GPR115	Q8IZF3	695	349	397	do not undergo cleavage	76.5	-	-
VI	ADGRF5	GPR116	Q8IZF2	1346	954	1003	990-991	148.1	110.3	39.2
VII	ADGRB1	BAI1	O14514	1584	884	939	926-927	174.2	103.3	72.4
VII	ADGRB2	BAI2	O60241	1585	874	924	911-912	174.4	101.6	74.1
VII	ADGRB3	BAI3	O60242	1522	819	869	-	167.4	95.6	71.8
VIII	ADGRG1	GPR56	Q9Y653	693	346	395	382-383	76.2	43.5	34.2
VIII	ADGRG2	GPR64	Q8IZP9	1017	570	619	606-607	111.9	68.1	45.2
VIII	ADGRG3	GPR97	Q86Y34	549	215	262	249-250	60.4	28.8	33.0
VIII	ADGRG4	GPR112	Q8IZF6	3080	2685	2734	2721-2722	338.8	300.7	39.5
VIII	ADGRG5	GPR114	Q8IZF4	528	189	239	226-227	58.1	26.3	33.2
VIII	ADGRG6	GPR126	Q86SQ4	1221	803	853	840-841	134.3	93.8	41.9
VIII	ADGRG7	GPR128	Q96K78	797	383	428	-	87.7	47.1	40.6
IX	ADGRV1	VLGR1; MASS1	Q8WXG9	6306	5856	5903	5890-5891	693.7	649.3	45.8