Normal Tissue Gallery- GTX04442

Adrenal gland: Individual cells or small groups of normally appearing adrenocortical cells can occasionally show a weak to moderate p16 immunostaining.

Aorta, media

Appendix, mucosa: Few individual cells or small groups of cells with weak to moderate p16 immunostaining can occasionally occur in gastrointestinal epithelium.

Appendix, muscular wall

Breast: Few individual luminal epithelial cells with weak to moderate p16 immunostaining can occasionally occur.

Bronchus, mucosa

Cerebellum (molecular layer)

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa: Few individual cells with weak to moderate p16 immunostaining can occasionally occur in gastrointestinal epithelium.

Ectocervix

Endocervix

Endometrium, proliferation

Endometrium, proliferation: Some glands with weak to moderate p16 immunostaining in the majority of cells can be seen in the histologically normal endometrium (not in all cases).

Endometrium, secretion: Some glands with weak to moderate p16 immunostaining in the majority of cells is often seen in the histologically normal endometrium.

Epididymis

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa

Kidney, cortex

Kidney, medulla

Liver

Lung

Lymph node

Ovary, stroma

Pancreas- A fraction of cells of islets of Langerhans show a moderate p16 staining

Parathyroid

Parotid gland

Pituitary gland, anterior lobe: A subset of cells of the adenohypophysis regularly show a moderate to strong p16 immunostaining.

Pregnant uterus (decidua)

Placenta, early

Placenta, mature

Placenta, mature: A weak to moderate p16 immunostaining can occur in stroma cells of the placenta (only in individual cases)

Placenta (amnion and chorion)

Prostate: Basal cells can show a weak to moderate p16 staining.

Rectum, mucosa

Seminal vesicle: Occasional coloration of the seminal vesicle epithelial cells is due to pigmentation (no true immunostaining).

Sinus paranasales: Few individual cells or groups of cells with weak to moderate p16 immunostaining can occasionally occur in respiratory epithelium.

Skin

Spleen

Stomach, antrum

Stomach, corpus

Striated muscle

Testis

Thymus: Some elements of corpuscles of Hassall’s stain p16 positive.

Thyroid gland

Tonsil: individual cells or small groups of normally appearing squamous epithelial cells of the crypts can occasionally show weak to moderate p16 immunostaining.

Tonsil, surface epithelium: Individual cells or small groups of normally appearing cells with weak to moderate p16 immunostaining can occasionally occur in the surface epithelium.

Urinary bladder, muscular wall

Urinary bladder, urothelium: Occasional cells or small groups of normally appearing cells with weak to moderate p16 immunostaining can occur in urothelium (here: mostly umbrella cells). Very rarely, this also applies to few stroma cells such as in this case.

Uterus, myometrium