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ACE2 antibody [MSVA-919R] HistoMAX™

Orthogonal HistoMAX
Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425
Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425
Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425

Cat. No. GTX04425

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 MSVA-919R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($679),
100 μl ($299)
See all ACE2 products
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
Not tested in other applications.

Calculated MW

92 kDa. ( Note )

Positive Control

Kidney: Cells of proximal tubuli should show a moderate to strong ACE2 immunostaining with accentuation of the staining at the apical membrane.

Negative Control

Kidney: Cells of distal tubuli and glomeruli should not show ACE2 immunostaining.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (around aa705-805) of human ACE2

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

angiotensin I converting enzyme 2 , ACEH

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Cytoplasm

Background

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425

GTX04425 IHC-P Image

IHC-P analysis of human testis tissue section using GTX04425 ACE2 antibody [MSVA-919R] HistoMAX™.
Leydig cells and spermatocytes of the testis show a particularly strong ACE2 immunostaining in the testis.

Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425

GTX04425 IHC-P Image

IHC-P analysis of human kidney cortex tissue section using GTX04425 ACE2 antibody [MSVA-919R] HistoMAX™.
A strong ACE2 immunostaining occurs in proximal tubuli of the kidney.

Anti-ACE2 antibody [MSVA-919R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04425

GTX04425 IHC-P Image

IHC-P analysis of human clear cell renal cell carcinoma tissue section using GTX04425 ACE2 antibody [MSVA-919R] HistoMAX™.
Clear cell renal cell carcinoma strong strong membraous ACE2 positivity.

REFERENCE

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REVIEW

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Package List Price ($)
$ 679
$ 299