*Optimal dilutions/concentrations should be determined by the researcher.
This antibody detects a band of approximately 36kDa in MCF7 cell lysates.
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Not tested in other applications.
This antibody recognises human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7 kDa nuclear protein.
PBS, 0.02% Sodium Azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
An 18 amino acid peptide from near the amino terminus of human BRCC36.
Purified by affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Brca1/Brca2-Containing Complex Subunit 3,Brcc36,C6.1A,Cxorf53,Brcc3
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
GTX31248 IHC-P Image
IHC-P analysis of human brain tissue using GTX31248 BRCC36 antibody.
GTX31248 WB Image
WB analysis of MCF-7 cell lysate using GTX31248 BRCC36 antibody at (A)0.5, (B)1 and (C)2 ug/ml.