PRODUCT
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Positive Control
Colon: A moderate to strong elastin immunostaining should be seen of fibres in the lamina propria, around smooth muscle cells of the muscularis mucosae, and in blood vessels (subendothelial).
Negative Control
Colon: Elastin immunostaining should be absent in all epithelial cells.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.05% BSA (Please contact us for PBS only format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant full-length human Elastin protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
elastin , ADCL1 , SVAS , WBS , WS
Cellular Localization
Secreted, extracellular space, extracellular matrix
Background
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/templates/default/js/lightbox/images/loading.gif "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
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GTX04466 IHC-P Image
IHC-P analysis of human testis tissue using GTX04466 Elastin antibody [MSVA-648R] HistoMAX™.
High density of elastin fibres along smooth muscles surrounding tubuli of the testis.
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GTX04466 IHC-P Image
IHC-P analysis of human bronchial mucosa tissue using GTX04466 Elastin antibody [MSVA-648R] HistoMAX™.
High content of elastin fibres along the bronchus mucosa.
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GTX04466 IHC-P Image
IHC-P analysis of human mucosa from descending colon tissue using GTX04466 Elastin antibody [MSVA-648R] HistoMAX™.
Elastin fibres predominate in the lamina propria around smooth muscle cells of the muscularis mucosae and in blood vessels.
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REFERENCE
There are currently no references for Elastin antibody [MSVA-648R] HistoMAX™ (GTX04466). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Elastin antibody [MSVA-648R] HistoMAX™ (GTX04466). Be the first to share your experience with this product.
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/small/GTX04466/GTX04466_20230728_IHC-P_49_23072722_980.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/small/GTX04466/GTX04466_20230728_IHC-P_179_23072723_144.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/small/GTX04466/GTX04466_20230728_IHC-P_309_23072723_130.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/normal/GTX04466/GTX04466_20230728_IHC-P_49_23072722_980.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/normal/GTX04466/GTX04466_20230728_IHC-P_179_23072723_144.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")
![Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466](/upload/website/prouct_img/normal/GTX04466/GTX04466_20230728_IHC-P_309_23072723_130.webp "Anti-Elastin antibody [MSVA-648R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04466")