IL12B / IL12 p40 ELISA pair [MT86/221/MT618]

Cat. No. GTX03072

Application	ELISA, Sandwich ELISA
Reactivity	Human
Package	1 pair ($659)

See all IL12B / IL12 p40 products

Datasheet

View product citations for antibody GTX03072 on CiteAb

PRODUCT

Product Content

GTX02956-02

Type : Detection antibody

Host : Mouse

Conjugation : Biotin

Package : 250 μg

GTX02957

Type : Capture antibody

Host : Mouse

Conjugation : Unconjugated

Package : 250 μg

APPLICATION

Product Note

GTX02957 (MT86/MT221) is able to detect native and recombinant human p40 subunit of IL-12 and IL-23. In combination with GTX02956-02 (MT618), it recognizes p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40 + p35), and IL-23 heterodimer (p40 + p19).

PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 12B , CLMF , CLMF2 , IL-12B , IMD28 , IMD29 , NKSF , NKSF2

Cellular Localization

Secreted

Background

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Database

Gene ID: 3593 IL12B
UniProt: P29460 IL12B

Research Area

DATA IMAGES

GTX03072 ELISA Image

Sandwich ELISA analysis of human IL-12/-23 (p40) protein using GTX02957 IL12B / IL12 p40 antibody [MT86 + MT221] as coating antibody and GTX02956-02 IL12B / IL12 p40 antibody [MT618] (Biotin) as detecting antibody.
Substrate : pNPP

REFERENCE

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REVIEW

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Package

List Price ($)

1 pair

$ 659

Qty