PRODUCT
Product Content
GTX02956-02
Type :
Detection antibody
Host :
Mouse
Conjugation :
Biotin
Package :
250 μg
GTX02957
Type :
Capture antibody
Host :
Mouse
Conjugation :
Unconjugated
Package :
250 μg
APPLICATION
Product Note
GTX02957 (MT86/MT221) is able to detect native and recombinant human p40 subunit of IL-12 and IL-23. In combination with GTX02956-02 (MT618), it recognizes p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40 + p35), and IL-23 heterodimer (p40 + p19).
PROPERTIES
Form
Liquid
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
interleukin 12B , CLMF , CLMF2 , IL-12B , IMD28 , IMD29 , NKSF , NKSF2
Cellular Localization
Secreted
Background
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX03072 ELISA Image
Sandwich ELISA analysis of human IL-12/-23 (p40) protein using GTX02957 IL12B / IL12 p40 antibody [MT86 + MT221] as coating antibody and GTX02956-02 IL12B / IL12 p40 antibody [MT618] (Biotin) as detecting antibody. Substrate : pNPP
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REFERENCE
There are currently no references for IL12B / IL12 p40 ELISA pair [MT86/221/MT618] (GTX03072). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for IL12B / IL12 p40 ELISA pair [MT86/221/MT618] (GTX03072). Be the first to share your experience with this product.