PRODUCT
Summary
This antibody was validated on 76 different Normal Tissues by IHC-P.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Calculated MW
Positive Control
Skin: A strong KLK7 staining should be seen in the stratum granulosum and possibly also in the keratinizing cell layers.
Negative Control
Colon: KLK7 immunostaining should be absent in all cells of the colon mucosa
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human KLK7 protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
kallikrein related peptidase 7 , PRSS6 , SCCE , hK7
Cellular Localization
Secreted
Background
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Database
Research Area
DATA IMAGES
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/templates/default/js/lightbox/images/loading.gif "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
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GTX04475 IHC-P Image
IHC-P analysis of human squamous cell carcinoma tissue section using GTX04475 Kallikrein 7 antibody [MSVA-707M] HistoMAX.
Squamous cell carcinoma showing strong Kallikrein 7 staining in areas of keratinization.
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GTX04475 IHC-P Image
IHC-P analysis of human colon mucosa tissue section using GTX04475 Kallikrein 7 antibody [MSVA-707M] HistoMAX.
Kallikrein 7 staining is absent in all cells of the colon mucosa.
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GTX04475 IHC-P Image
IHC-P analysis of human skin tissue section using GTX04475 Kallikrein 7 antibody [MSVA-707M] HistoMAX.
A strong Kallikrein 7 staining in the stratum granulosum and the keratinizing superficial layer of the skin.
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REFERENCE
There are currently no references for Kallikrein 7 antibody [MSVA-707M] HistoMAX (GTX04475). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Kallikrein 7 antibody [MSVA-707M] HistoMAX (GTX04475). Be the first to share your experience with this product.
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/small/GTX04475/GTX04475_20230728_IHC-P_70_23072722_439.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/small/GTX04475/GTX04475_20230728_IHC-P_200_23072723_202.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/small/GTX04475/GTX04475_20230728_IHC-P_330_23072723_151.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/normal/GTX04475/GTX04475_20230728_IHC-P_70_23072722_439.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/normal/GTX04475/GTX04475_20230728_IHC-P_200_23072723_202.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")
![Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475](/upload/website/prouct_img/normal/GTX04475/GTX04475_20230728_IHC-P_330_23072723_151.webp "Anti-Kallikrein 7 antibody [MSVA-707M] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04475")